All webinars take place at 1pm EST.  View the listing below for the schedule and complete abstracts. 

Monday, December 10, 2018
1:00 PM - 2:00 PM Antibody Validation for Clinical Studies: The Good, The Bad and The Ugly  
Presented by David Krull, HT(ASCP)QIHC, Senior Scientific Investigator, GlaxoSmithKline

Many think that antibodies are a major driver of what has been deemed a ‘reproducibility crisis’; however, the real culprit lies in the use of poorly characterized antibodies. Investigators are too often misled by deceptive marketing practices and website claims of validated antibodies. The road to accurate and reproducible immunohistochemistry begins with careful antibody validation carried out “in context”; ie, using the tissues required for the proposed study. The best way to carry out “in context” validation is the use of “paired” frozen and FFPE fixed materials, providing FFPE is the fixative used in the study (typical for clinical studies). Orthogonal approaches, such as western blotting, are perhaps the best avenue to take, and fortunately have become relatively easy to carry out with the recent offering of convenient pre-packaged regents and accessories by several leading vendors. In parallel, many “antibody companies” also offer prepared tissue and cell lysates for prominent cellular pathways utilized in significant disease areas, and matched to their antibody offerings. These include “baseline” and “stimulated” cell lysates (especially useful for phosphorylation studies), overexpression lysates for selected target proteins, and purified proteins, all useful as positive controls in western blotting experiments. Taken together, these commercial advances enable the beginning-to-intermediate level investigator to carry out straight-forward antibody validation for their specific projects.
Tuesday, December 11, 2018
1:00 PM - 2:00 PM Immunohistochemical Staining in the Mohs Lab
Presented by Jon Hetts, HT(ASCP), Lab Manager, Oregon Health & Science University

The utilization of Immunohistochemical staining in the Mohs lab has become more common place. Advances in micro polymer detection kits have allowed for ever more rapid and reliable immunostaining protocols. Immunohistochemical stains aid in the diagnosis and treatment of a large range of cutaneous malignancies in addition to non-melanoma skin cancers such as melanocytic neoplasms, dermatofibrosarcoma, and Paget’s disease. This course will go over the fundamentals of deploying immunostaining in the Mohs lab, the utility of certain antibodies, optimizing your protocols, quality control, and how to trouble shoot common issues.
Wednesday, December 12, 2018
1:00 PM - 2:00 PM IHC in Hempath
Presented by Sheron Lear, HT(ASCP)HTL, QIHC, R&D, Education, CPA Lab

Immunohistochemistry on any tissues can be a challenge; however, this challenge can often magnify if a diagnosis of a complicated hempath disease process is anticipated. To aid the pathologist in making an accurate diagnosis, good fixation, processing, sectioning, pretreatment and proper validation of the antibodies is essential. This webinar will include suggestions for validating the antibodies, the use of low and high expressers when necessary, decal solutions that help preserve antigens thus rendering an accurate diagnosis for the patient.
Thursday, December 13, 2018
1:00 PM - 2:00 PM Diagnostic Panels: What's New In The World of IHC  
Presented by Debra Freeman, Technical Consultant, Cell Marque

In this workshop we will explore diagnostic markers that may be new to the audience. We will look at staining characteristics, unique applications and the diagnostic advantages of these novel antibodies. We will discuss diagnostic algorithms, an important tool pathologists use not only to diagnose specific tumors, but also to exclude certain conditions from the diagnosis. Understanding how these panels are developed and why certain antibodies are included is important for understanding the role of immunohistochemistry in the field of pathology. This workshop is designed to familiarize the audience with novel and routine antibodies and their applications. In addition, it will underline the importance of diagnostic panels to pathologists.
Friday, December 14, 2018
1:00 PM - 2:00 PM 2018 Focused Update of the HER2 Breast Guidelines
Review of the 2018 ASCO/CAP issued clinical practice guideline focused update on HER2 testing in breast cancer.
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